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1.
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity.
Nat Mater
; 21(6): 710-720, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35606429
2.
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.
Nature
; 534(7606): 272-6, 2016 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27279227
3.
Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives.
Bioorg Med Chem
; 25(8): 2336-2350, 2017 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28302507
4.
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.
Bioorg Med Chem Lett
; 26(17): 4296-300, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27476141
5.
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
Bioorg Med Chem
; 21(17): 5488-502, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23816042
6.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.
Bioorg Med Chem
; 20(15): 4680-92, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22763369
7.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
Bioorg Med Chem
; 20(18): 5600-15, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22883026
8.
TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies.
Cancer Res Commun
; 2(6): 489-502, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36923556
9.
Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
ACS Infect Dis
; 7(6): 1680-1689, 2021 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33929818
10.
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
ACS Med Chem Lett
; 11(8): 1645-1652, 2020 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34345355
11.
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
J Med Chem
; 63(6): 3215-3226, 2020 03 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32142284
12.
Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy.
PLoS One
; 12(10): e0186587, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29065190
13.
A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
Cancer Cell
; 31(3): 424-435, 2017 03 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28292440
14.
A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity.
PLoS One
; 10(12): e0144675, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26649895
15.
Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents.
J Med Chem
; 58(20): 8036-53, 2015 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-26372373
16.
Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells.
Nat Commun
; 6: 7668, 2015 Jul 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26144554
17.
Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma.
Cancer Res
; 73(23): 7043-55, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24121489
18.
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.
J Med Chem
; 56(16): 6478-94, 2013 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23906342
19.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.
J Med Chem
; 55(7): 3452-78, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22376051
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